Kisspeptin-10 peptide is a peptide substance with multiple biological activities, especially with extensive research value in the fields of biology and medicine. The molecular formula is usually C63H83N17O15 (for rat sources) or C63H83N17O14 (for human sources), CAS 374675-21-5. For rat sources, its molecular weight is approximately 1318.44; For human sources, the molecular weight is approximately 1302.44. It can regulate the excitability and synaptic transmission of neurons, and participate in the formation and maintenance of neural circuits. Widely distributed in the brain, it interacts with various neurotransmitters and neuromodulators to jointly regulate the function of the nervous system. It also has potential medical application value. Due to its important role in the reproductive and nervous systems, it may become a candidate for new drugs to treat some diseases related to the reproductive and nervous systems. For example, in the field of reproductive system diseases, it may be used to treat issues such as sexual dysfunction and infertility. In the field of neurological diseases, it may be used to regulate the excitability of neurons, treat neurodegenerative diseases, depression, etc.
|
Customized Bottle Caps And Corks:
|
|
|
Chemical Formula |
C63H83N17O14 |
|
Exact Mass |
1302 |
|
Molecular Weight |
1302 |
|
m/z |
1302 (100.0%), 1303 (68.1%), 1304 (22.8%), 1303 (5.9%), 1305 (5.0%), 1304 (4.3%), 1304 (2.9%), 1305 (2.0%), 1305 (1.3%) |
|
Elemental Analysis |
C, 58.10; H, 6.42; N, 18.28; O, 17.20 |
Kisspeptin-10 peptide is an important peptide substance that plays multiple functions in organisms, especially in the reproductive and nervous systems. By interacting with the GPR54 receptor, it participates in regulating various physiological processes, including puberty development, reproductive cycle, sexual behavior, energy metabolism, and neuronal excitability and synaptic transmission.
Firstly, it has significant functions in the reproductive system. It is a natural ligand of the GPR54 receptor that regulates the secretion of gonadotropin-releasing hormone (GnRH) by activating the receptor. GnRH is a key factor in regulating hormone secretion along the reproductive axis, and is crucial for controlling adolescent development and the reproductive cycle. The binding to the GPR54 receptor can stimulate the activity of GnRH neurons, thereby promoting the release of GnRH. This function plays a crucial role in regulating reproductive function and is of great significance for reproductive health.
it also plays an important role in the nervous system.
Secondly, it also plays an important role in the nervous system. It is widely distributed in multiple regions of the brain and interacts with various neurotransmitters and neuromodulators. It can regulate the excitability and synaptic transmission of neurons, and participate in the formation and maintenance of neural circuits. Research has shown that it plays an important role in regulating sexual behavior, emotional responses, and cognitive function. By affecting the activity of neurons and synaptic transmission efficiency, it is possible to regulate the functional state of the nervous system, thereby affecting individual behavior and psychological state.
In addition, it also has the function of regulating energy metabolism. It can affect appetite and energy balance, participate in regulating fat metabolism and glucose homeostasis. By affecting the appetite regulation center in the hypothalamus, it regulates feeding behavior and energy expenditure. This function makes it a potential target for treating obesity and metabolic diseases. By regulating its activity, it may help improve an individual's energy metabolism status, prevent and treat related diseases.
it may also have other potential biological activities
In addition to the above functions, it may also have other potential biological activities. For example, some studies suggest that it may be involved in regulating immune system function, cardiovascular system function, and neoplasm development processes. The discovery of these functions provides possibilities for their application in more fields and also provides new directions for their research in the medical field.
In terms of medical applications, research has broad prospects. Firstly, in the field of reproductive medicine, it can serve as a potential drug candidate for treating diseases such as sexual dysfunction and infertility. By regulating its activity, it can promote the secretion of GnRH, thereby improving reproductive function. Secondly, in the field of neurological and psychiatric disorders, it may be used to treat emotional disorders such as depression and anxiety, as well as cognitive impairment and other diseases. By regulating the functional state of the nervous system, it may help improve an individual's psychological state and behavioral performance. In addition, it may also become a new drug candidate for treating obesity and metabolic diseases, improving individual health by regulating energy metabolism status.
Metastin (45-54), as a peptide substance, has a series of special characteristics in the fields of biology and medicine. The following are several notable features:
It is an effective endogenous GPR54 agonist. GPR54, also known as KISS1 receptor, is a G protein coupled receptor. Metastin (45-54) plays a crucial role in regulating hormone secretion along the reproductive axis by binding to GPR54 and activating its downstream signaling pathway. This characteristic enables metastin (45-54) to play a crucial role in multiple aspects such as adolescent development, reproductive cycle, and sexual behavior.
It also plays an important role in energy metabolism and the nervous system. It can affect appetite and energy balance, participate in regulating fat metabolism and glucose homeostasis. Meanwhile, metastin (45-54) is widely distributed in the brain and interacts with various neurotransmitters and neuromodulators to jointly regulate the function of the nervous system. These functions make metastin (45-54)have potential applications in the treatment of obesity, metabolic disorders, and neurological and psychiatric disorders.
It has a dual function, serving as both a vasoconstrictor and an inhibitor of angiogenesis. This feature has potential application value in the cardiovascular system. Regulating vascular tension and angiogenesis may be of great significance for the treatment and prevention of cardiovascular diseases.
Showing unique effects in neoplasm metastasis inhibition. Research has shown that it acts as a neoplasm metastasis suppressor through its receptor GPR54. Activation can inhibit human lung melanoma, and it has also been confirmed as a metastasis inhibitor in breast cancer cells. These findings provide potential possibilities for their application in the field of neoplasm therapy.
Kisspeptin-10 peptide, as a short peptide molecule with a wide range of biological activities, mainly acts by specifically binding to its exclusive receptor GPR54 (also known as KISS1R) to trigger a series of complex intracellular signal transduction processes, thereby exerting various important biological functions. It plays an indispensable role in multiple physiological systems and pathological processes of the body.
In terms of regulating the reproductive system, activating GPR54 receptors becomes a key regulatory factor for regulating hormone secretion in the reproductive axis. This regulatory effect has a significant and profound impact on the physiological processes of the body, covering multiple important stages from puberty development, maintenance of reproductive cycle regularity, to normal expression of sexual behavior. Specifically, when it binds to the GPR54 receptor, it can accurately stimulate the hypothalamus to secrete gonadotropin-releasing hormone (GnRH). GnRH, as a key neurohormone, further acts on the anterior pituitary gland, promoting its secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH).
These gonadotropins then reach the gonads (ovaries or testes) through blood circulation, regulating the synthesis and secretion of gonadotropins, thereby achieving precise regulation of reproductive system function. For example, during puberty, an increase in its levels triggers a series of reproductive endocrine changes, promoting the maturation of sexual organs and the emergence of secondary sexual characteristics; During the reproductive cycle, it participates in regulating the menstrual cycle and ovulation process, ensuring the normal functioning of reproductive activities; In terms of sexual behavior, it also indirectly regulates libido and sexual performance by affecting sex hormone levels.
It also plays a crucial role in the development of embryonic kidneys. Research has shown that the metastin (45-54)-10-GPR54 system plays an essential regulatory role in various critical stages of embryonic kidney development, and is crucial for the normal morphogenesis and functional maturation of the kidney. In the early stages of embryonic development, this system is involved in the formation and differentiation of renal primordia, guiding the proper migration and aggregation of precursor cells of nephrons, ensuring the correct construction of the basic structure of the kidney.
As the embryo further develops, it regulates the generation and development of renal blood vessels by binding to GPR54 receptors, providing sufficient blood supply to the kidneys to meet their growing metabolic needs. In addition, it also participates in regulating the proliferation, differentiation, and apoptosis of kidney cells, maintaining the normal quantity and functional status of kidney cells, thereby ensuring that the kidneys can perform important physiological functions such as excretion, fluid balance regulation, and endocrine regulation. If there are abnormalities in the metastin (45-54)-10-GPR54 system during embryonic kidney development, it may lead to kidney developmental abnormalities or functional disorders, causing a series of congenital kidney diseases.
It also has significant anti-tumor metastasis effects, which has attracted much attention in the field of neoplasm research. Neoplasm metastasis is one of the main causes of death in malignant neoplasms, and kisspeptin-10 peptide can inhibit the metastasis and spread of neoplasm cells from multiple links by activating GPR54 receptor. On the one hand, it can directly act on neoplasm cells, regulating signaling pathways related to migration and invasion within neoplasm cells, inhibiting their motility and secretion of matrix degrading enzymes, thereby reducing their ability to penetrate the basement membrane and vascular walls, and preventing them from entering the bloodstream and lymphatic system for distant metastasis.
On the other hand, it can also regulate the neoplasm microenvironment, affect the activity and function of neoplasm associated fibroblasts, immune cells, and other stromal cells, inhibit neoplasm angiogenesis, and cut off the nutritional supply and metastasis channels of neoplasm cells. Based on these anti-tumor metastasis mechanisms, they have become potential targets for tumor therapy, providing new ideas and directions for the development of novel anti-tumor drugs. At present, a large number of studies have been devoted to exploring how to use this substance or its analogues to inhibit neoplasm metastasis, improve the survival rate and quality of life of cancer patients.
It is also an effective vasoconstrictor and angiogenesis inhibitor, playing an important role in the cardiovascular system. In terms of vascular tone regulation, by binding to the GPR54 receptor on vascular smooth muscle cells, the intracellular signal transduction pathway is activated, causing vascular smooth muscle contraction and reducing vascular diameter, thereby increasing vascular resistance and raising blood pressure. This vasoconstrictive effect is of great significance in the body's response to physiological stress (such as exercise, tension, etc.), as it can help the body quickly adjust blood circulation and meet the blood supply needs of important organs. However, in certain pathological conditions, such as hypertension, overexpression or increased activity may lead to excessive vasoconstriction, exacerbating blood pressure elevation and participating in the occurrence and development of hypertension.
In terms of regulating angiogenesis, the inhibition of angiogenesis is achieved by suppressing the proliferation, migration, and lumen formation of endothelial cells. Angiogenesis is necessary in many physiological processes (such as wound healing, embryonic development, etc.), but in neoplasm growth and some eye diseases (such as diabetes retinopathy), abnormal angiogenesis will promote disease progression. Therefore, the inhibitory effect on angiogenesis makes it potentially valuable for the treatment and prevention of cardiovascular diseases. For example, by regulating the level or activity of metastin (45-54), it may help control the blood supply to neoplasms and inhibit neoplasm growth; In the treatment of eye diseases, it may help to inhibit the formation of abnormal neovascularization and protect vision.
FAQ
What are the benefits of metastin (45-54) peptide?
Kisspeptin peptide benefits center on its role as a master hormone regulator, primarily boosting reproductive health by stimulating natural testosterone and estrogen production, improving libido, enhancing fertility in conditions like PCOS, and aiding ovulation in IVF. It also shows promise in improving mood, energy, metabolism, and potentially suppressing tumors, offering a safer alternative to some traditional fertility drugs by working with the body's natural hormonal pathways.
Does kisspeptin-10 peptide increase muscle growth?
By increasing LH and FSH levels, kisspeptin and its agonists can elevate testosterone production, particularly in males. Testosterone is a well-known anabolic steroid that increases muscle mass, strength, and recovery, providing a potential advantage in athletic performance (doping).
What peptide is best for testosterone?
Two such peptides are kisspeptin-10 and gonadorelin. In one study, kisspeptin-10 increased the average serum testosterone levels within 24 hours of injection.
What is the no. 1 testosterone booster?
There's no single "number 1" testosterone booster, but studies highlight ingredients like Ashwagandha, Tongkat Ali, Fenugreek, Magnesium, and Vitamin D for potential benefits, with Ashwagandha often cited for reducing stress and boosting testosterone in some men, and Tongkat Ali for fatigue. Lifestyle changes, particularly exercise (weightlifting) and a healthy diet, are proven to have a greater impact on natural testosterone levels than most supplements. Always consult a doctor before starting any supplement.
Hot Tags: kisspeptin 10 peptide cas 374675-21-5, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, 1 3 dibromo 2 5 difluoro 4 6 dimethylbenzene, 2 5 dibromo 1 1 4 1 terphenyl, CAS 737 53 1, CAS 1247053 55 9, CAS 606129 90 2, 5 1 1 biphenyl 3 yl 8 1 1 biphenyl 4 yl 5 8 dihydroindolo 2 3 c carbazole