Tianepine sodium salt(link:https://www.bloomtechz.com/synthetic-chemical/api-researching-only/tianeptine-sodium-salt-cas-30123-17-2.html), also known as Tianepine sodium salt, is an organic compound with various biological activities that is widely studied and used in clinical and scientific fields. The molecular structure of Tianepine consists of a triazole ring, a chlorophenyl heterocycle, and a naphthalene ring, with four oxygen atoms and two nitrogen atoms. Its molecular formula is C21H25ClN2O4S, with a molecular weight of 437.0, and it belongs to the tricyclic compound. The main pharmacological effect is to regulate the uptake and release of the neurotransmitter 5-hydroxytryptamine (5-HT) to exert antidepressant, anti anxiety, improve memory and cognitive function, neuroprotective, and anti fatigue effects. Its mechanism of action is unique and different from other commonly used antidepressants. It has an anti anxiety effect and can increase the concentration of 5-HT and norepinephrine in the brain, while regulating dopamine and γ- The level of aminobutyric acid. This enables Tianepine to alleviate anxiety related symptoms such as generalized anxiety disorder and social phobia. It can improve memory and cognitive function, mainly by increasing the concentration of dopamine and norepinephrine in the brain and regulating the release of brain-derived neurotrophic factors. This allows Tianepine to be used to treat neurocognitive disorders such as attention deficit hyperactivity disorder.
As the product has a wide range of uses, people are increasingly interested in its research methods. In the following description, we will provide a detailed description of common synthesis methods.
Method 1
Preparation of raw materials:
(1) O-Nitrochlorobenzene
O-nitrochlorobenzene is a common organic synthesis raw material that can be obtained through purchase or chemical synthesis methods. The structural formula of o-nitrochlorobenzene is C6H4ClNO2, with a molecular weight of 153.5.
(2) Sodium nitrite
Sodium nitrite is an inorganic salt that can be prepared by the reaction of soda ash and nitric acid, or directly purchased. The structural formula of sodium nitrite is NaNO2, with a molecular weight of 69.0.
(3) Ammonium chloride
Ammonium chloride is an inorganic salt that is easily soluble in water and can be prepared by reacting ammonia and chlorine gas, or directly purchased. The structural formula of ammonium chloride is NH4Cl, with a molecular weight of 53.5.
(4) Water
Water is the most common solvent in the laboratory and can be used to dissolve raw materials and products.
Synthesis steps:
(1) Mix o-nitrochlorobenzene, sodium nitrite, ammonium chloride, and water together, heat to a boiling state, and the reaction time is about 30 minutes to 1 hour.
(2) After the reaction is completed, add an appropriate amount of sodium hydroxide solution to adjust the pH value to around 7, then add an appropriate amount of activated carbon, heat and boil for a few minutes.
(3) Filter and remove activated carbon particles, cool the solution, and precipitate crystals. Stir with a glass rod and filter the crystals to obtain the crude Tianeptine product.
(4) Add the crude Tianeptine to an appropriate amount of water and heat it to a dissolved state. Add an appropriate amount of sodium hydroxide solution to adjust the pH value to around 7, then add an appropriate amount of activated carbon, heat and boil for a few minutes.
(5) Filter and remove activated carbon particles, cool the solution, and precipitate crystals. Stir with a glass rod and filter the crystals to obtain Tianeptine high-quality products.
(6) Wash and dry the Tianepine boutique to obtain the final product Tianepine sodium salt.
Method 2
Prepare raw materials
(1) O-Nitrochlorobenzene
O-nitrochlorobenzene is a common organic synthesis raw material that can be obtained through purchase or chemical synthesis methods. The structural formula of o-nitrochlorobenzene is C6H4ClNO2, with a molecular weight of 153.5.
(2) Aniline
Aniline is an organic synthetic raw material that can be prepared through the reaction of ammonia and chlorine gas or directly purchased. The structural formula of aniline is C6H7N, with a molecular weight of 109.1.
(3) Sodium acetate
Sodium acetate is an organic salt that is easily soluble in water and can be prepared by reacting acetic acid with sodium hydroxide, or directly purchased. The structural formula of sodium acetate is CH3COONa, with a molecular weight of 134.9.
(4) Salicylic acid
Salicylic acid is an organic acid that can be prepared by reacting salicylaldehyde with acetic anhydride or purchased directly. The structural formula of salicylic acid is C6H4 (OH) (COOH), with a molecular weight of 138.1.
(5) Water
Water is the most common solvent in the laboratory and can be used to dissolve raw materials and products.
Synthesis steps:
(1) Mix o-nitrochlorobenzene, aniline, sodium acetate, and salicylic acid together, heat to reflux state, and the reaction time is about 30 minutes to 1 hour.
(2) After the reaction is over, add an appropriate amount of hydrochloric acid. Sorry for the unexpected interruption of the previous answer. The following are the complete steps for the second common laboratory synthesis method of Tianeptine sodium salt:
(3) After the reaction is completed, add an appropriate amount of sodium hydroxide solution to adjust the pH value to around 7, then add an appropriate amount of activated carbon, heat and boil for a few minutes.
(4) Filter and remove activated carbon particles, cool the solution, and precipitate crystals. Stir with a glass rod and filter the crystals to obtain the crude Tianeptine.
(5) Add the crude Tianeptine to an appropriate amount of water and heat it to a dissolved state. Add an appropriate amount of sodium hydroxide solution to adjust the pH value to around 7, then add an appropriate amount of activated carbon, heat and boil for a few minutes.
(6) Filter and remove activated carbon particles, cool the solution, and precipitate crystals. Stir with a glass rod and filter the crystals to obtain high-quality Tianeptine.
(7) Wash and dry the Tianepine boutique to obtain the final product Tianepine sodium salt.