Tianeptine sodium salt(link:https://www.bloomtechz.com/synthetic-chemical/api-researching-only/tianeptine-sodium-salt-cas-30123-17-2.html), also known as aminopeptidin or sodium aminopeptidin, is an organic compound with the molecular formula C19H16N4Na2O4, CAS 30123-17-2, and a molecular weight of 408.34. It is a white to light yellow powder, insoluble in water, but soluble under acidic conditions. The molecular structure of this compound contains a benzene ring and four nitrogen atoms, with two nitrogen atoms forming two peptide bonds. The molecular structure of this compound also contains sodium ions and chloride ions, which form ion bonds with two oxygen atoms, respectively. Not soluble in water, but soluble under acidic conditions. It can be dissolved in organic solvents such as methanol, ethanol, chloroform, etc. Poor thermal stability and decomposition at high temperatures. Under heating conditions, the compound undergoes deamination and decarboxylation reactions, producing isoquinoline-3-carboxylic acid. It is acidic and can react with alkali to form salts. It can also react with acidic substances to form salts.
Tianeptine sodium salt, also known as aminopeptidin or sodium aminopeptidin, is an organic compound with a molecular formula of C19H16N4Na2O4 and a molecular weight of 408.34. The following are the main uses of the Tianeptine sodium salt:
1. Antidepressants
Tianepine sodium salt is a drug with antidepressant activity that is widely used to treat various types of depression, including mild to severe depression. It works by regulating the levels of neurotransmitters serotonin (5-HT) and norepinephrine (NE) in the brain. Compared with traditional antidepressants, it has different mechanisms of action and pharmacological characteristics, making it an effective antidepressant.
2. Antianxiety drugs
Tianepine sodium salt is also used to treat anxiety disorders and stress reactions. It alleviates anxiety and stress responses by increasing the levels of serotonin and norepinephrine in the brain, while also affecting dopamine (DA) and γ- The aminobutyric acid (GABA) system also has a certain regulatory effect. This makes it a drug with anti anxiety activity and widely used to treat various types of anxiety disorders.
3. Improve memory and cognitive function
Research has found that Tianepine sodium salt has a certain impact on neurotransmitters in the brain, which can improve memory and cognitive function. It promotes neuronal excitability and plasticity by increasing the levels of dopamine and norepinephrine in the brain, and improves performance in areas such as attention, reaction time, and emotional management. These effects can be applied to treat neurocognitive disorders such as attention deficit hyperactivity disorder (ADHD).
4. Neuroprotective agents
Tianepine sodium salt has neuroprotective effects and can protect the brain from various neurodegenerative diseases and brain damage. It exerts neuroprotective effects by regulating the levels of neurotransmitters serotonin and norepinephrine and increasing the release of brain derived neurotrophic factor (BDNF). These effects can be applied to treat neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease.
5. Antifatigue drugs
Tianepine sodium salt is used as an anti fatigue drug to alleviate physical fatigue and fatigue related symptoms. It improves the body's fatigue and emotional state by regulating the levels of neurotransmitters serotonin and norepinephrine and increasing the release of dopamine. These effects can be applied to treat fatigue related diseases such as chronic fatigue syndrome.
Tianeptine sodium salt, also known as Tianeptine sodium salt, is a new type of tricyclic antidepressant that exerts its antidepressant effect mainly by acting on the 5-HT system. It is also known as Tianepine, Thioneptin, Datilam, and Thiolapidine.
The pharmacological characteristics of Tianepine include its mechanism of action, in vivo processes, efficacy, and adverse reactions.
Mechanism of action: The mechanism of action of Tianepine mainly involves the neurotransmitters serotonin and norepinephrine. It is a 5-HT absorption enhancer that can increase the concentration of 5-HT in the brain, thereby regulating 5-HT signaling. This mechanism is different from other traditional antidepressants, which mainly increase the concentration of 5-HT by inhibiting its reuptake.
In vivo process: After oral administration of Tianepine sodium salt, the gastrointestinal tract can quickly and completely absorb it. Pharmacokinetic studies have shown that after oral administration of 12.5mg, the peak blood concentration can be reached at approximately 0.79-1.8 hours, with a peak blood concentration of 246ng/ml. Tianepine is rapidly and widely distributed in the body, with a protein binding rate of up to 94%. It is mainly metabolized through the liver, through β- Oxidation and N-demethylation are converted into other compounds. Only a small amount of prototype compounds (about 8%) are excreted from the kidneys, while the majority are excreted in the form of metabolites from the urine.
Pharmacodynamics: Tianepine is mainly used to treat depression and has a good effect on mood disorders. It can also significantly improve physical discomfort symptoms, especially gastrointestinal discomfort symptoms related to anxiety and mood disorders. In clinical studies, Tianepine has shown good efficacy and good tolerance. For example, a study showed that about 70% of patients with depression who took Tianepine showed significant improvement in their depressive symptoms after 8 weeks.
Adverse reactions: Tianepine's adverse reactions include dry mouth, constipation, dizziness, nausea, insomnia, etc. Dry mouth and constipation are the most common adverse reactions, with an incidence rate of 10% to 20%. Dizziness and nausea are usually mild, with an incidence of 5% to 10%. Insomnia is more common in the early stages of treatment and is usually temporary.
Overall, the pharmacological properties of Tianepine indicate that it has antidepressant effects while also exhibiting some adverse reactions. When using, it is necessary to follow the specifications of medical advice and drug instructions.