Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of terbinafine hydrochloride spray in China. Welcome to wholesale bulk high quality terbinafine hydrochloride spray for sale here from our factory. Good service and reasonable price are available.
Terbinafine hydrochloride spray is a topical antifungal medication whose principal active component is terbinafine hydrochloride, a synthetic compound belonging to the allylamine class of antifungals. It acts by specifically inhibiting the fungal enzyme squalene epoxidase, thereby interrupting the biosynthesis of ergosterol-a critical structural component of the fungal cell membrane. This inhibition leads to the intracellular accumulation of squalene, disrupting membrane integrity and ultimately exerting both fungicidal and fungistatic effects. The formulation demonstrates potent activity against a broad spectrum of clinically relevant pathogenic fungi, including dermatophytes and Malassezia species, which are commonly implicated in superficial fungal infections.
This medicine is prepared with ethanol, propylene glycol and other auxiliary materials to form a stable solution system, which has the following characteristics:
Strong permeability: Ethanol carrier promotes medicine penetration and thickening of the stratum corneum, directly reaching the site of infection, especially suitable for deep-seated fungal permeates such as tinea pedis and tinea corporis.
Convenient to use: The quantitative nozzle design can evenly cover epidermis folds and hair dense areas (such as groin and sole), reduce hand contact, lower the risk of cross permeate, and significantly improve patient compliance compared to traditional cream formulations.
High safety: The transdermal absorption rate is less than 5%, the system exposure is extremely low, and the blood medicine concentration can be ignored, avoiding the liver toxicity risk of oral antifungal medicine. Children and elderly people over 2 years old can use it safely.
Additional information of chemical compound:
Our product form
terbinafine hydrochloride +. COA
Basic Product Information
1. Ingredients and dosage forms
The core component of terbinafine hydrochloride spray is tebinaceil hcl, which belongs to the class of acrylamide antifungal medicine. Its dosage form is medicine, usually with ethanol, propylene glycol, polyoxyethylene stearate and water as auxiliary materials to form a stable solution system. For example, every 125 mL of a brand medicine contains 1.25 mL of tebinaceil hcl (concentration 1%), and ethanol is added as a solvent and penetration enhancer. Propylene glycol enhances medicine solubility, and polyoxyethylene stearate is used as a surfactant to optimize mist uniformity.
2. Specifications and packaging
The common specification is 30mL or 125mL bottle, equipped with quantitative nozzle, which can achieve single accurate administration. For example, the 30mL pump bottle contains 290mg tebinaceil hcl, and the nozzle design supports inverted use, which is convenient for covering special parts such as feet. The packaging is made of light resistant materials to ensure medicine stability, and the storage conditions are from 5 ℃ to 25 ℃ (41 ℉ to 77 ℉) to avoid freezing.
1. Standard medication process
Unpolluted the epidermis: Wash and dry the affected area before use to ensure there is no residual moisture or dirt.
First use: press the nozzle 3-10 times until the liquid medicine mist out evenly, remove the air and test the medicine effect.
Drug painting technique:
Drug evenly 10cm away from the affected area until the epidermis is moist (approximately 0.5-1mL/10cm ²).
The cure of tinea pedis should cover the interdigital, plantar, and lateral edges to avoid omissions.
Drying time: After using, wait for 1-2 minutes for the medicine to naturally dry and form a protective film.
Follow up cure: Wash hands after use to avoid contact with healthy epidermis or mucous membranes.
2. Treatment management
Tinea corporis/tinea crus: Use continuously for 2-4 weeks until the epidermis lesions completely disappear.
Tinea pedis: The scaly keratinized type needs to be extended to 4-6 weeks to ensure complete removal of fungi.
Tinea versicolor: The cure course is 2 weeks, and maintenance therapy twice a week can reduce the recurrence rate.
Advantage analysis and clinical evidence
1. Formulation advantages
Strong permeability:
Ethanol carrier promotes drug penetration through the stratum corneum, and the concentration of drugs in the stratum corneum is 1.5 times that of cream when treating tinea pedis.
Convenient use:
the drug design reduces hand contact, reduces the risk of cross permeate, and patient compliance reaches 92% (78% for cream).
Good Cleanliness:
Easy to unpolluted, with a residue rate of less than 5%, suitable for use in areas with dense hair (such as the scalp).
2. Clinical research support
Efficacy comparison:
A study involving 36 healthy subjects showed that there was no significant difference between the medicine and the cream in terms of medicine concentration (AUC), Cmax and half-life in the stratum corneum, but the use of the mist was more satisfactory.
Recurrence rate:
Patients with tinea pedis were followed up for 6 months. The recurrence rate in the mist group was 15%, significantly lower than that in the cream group (30%, P<0.05).
1. Basic dose
Concentration and specification: the common specification is 1% solution (for example, the 125mL bottle contains 1.25mL tebinaceil hcl, or the 30mL pump mist bottle contains 290mg medicine).
Adults and animals over 2 years old (if approved by a veterinarian):
Tinea corporis/tinea crus: terbinafine hydrochloride spray once a day on the affected area, with a cure course of 7 days.
Tinea pedis/tinea versicolor:put on the affected area twice a day for 14 days; Scaled keratinized tinea pedis needs to be extended to 28 days.
Single dose: Use 1-2 times per square centimeter on the affected area, until the epidermis is moist but not dripping. For example, a single press of a 30mL pump bottle can release about 0.1mL of solution, covering an area of about 10cm ².
2. Special scene adjustment
Wide range of permeate: If the epidermis lesion area exceeds 10% of the body surface area, cure should be divided into different regions to avoid excessive medicine absorption.
Stubborn permeate: If the symptoms do not improve after the course of cure, it is necessary to stop taking the medication for 3 days and have a follow-up examination to rule out the possibility of medicine resistance or misdiagnosis.
3. Taboos and Caution
Contraindications: It is contraindicated for individuals allergic to tebinaceil hcl or excipients such as ethanol and propylene glycol.
Caution:
Chronic eczema and psoriasis lesions: may increase the risk of medicine absorption and irritation, and the risk benefit ratio needs to be evaluated.
Open wounds or damaged epidermis: Avoid direct mist, cover with sterile gauze first and then mist onto the gauze.
Detailed explanation of operation steps
1. Preparation before medication
unpolluting the affected area: Wash the infected area with warm water and neutral soap to remove scales and secretions. For erosive tinea pedis between toes, a cotton swab dipped in physiological saline should be used to unpolluted the gaps.
Drying cure: Use a unpolluted towel to pat dry or blow dry with a hair dryer in the cold air mode (15cm away from the epidermis) to ensure that there is no residual moisture.
Preparation of medication bottle: Shake the bottle vertically for 30 seconds before the first use to evenly distribute the medication; Press the nozzle 3-10 times until the medicine is mist out in a uniform mist.
2. Spray painting techniques
Distance and angle: Hold the medicine bottle 10cm away from the affected area and mist it vertically to avoid uneven distribution of the medicine due to tilting.
Coverage Area:
Tinea pedis: Put onto the toes, soles, sides of the feet, and around the nails, with a focus on covering the third and fourth toe gaps.
Tinea corporis/tinea crus: Put beyond the edge of the epidermis lesion by 2cm to form a protective ring.
Tinea versicolor: covers all pigment abnormal plaques, including areas of mild desquamation.
Spray amount: Based on the formation of a uniform film on the epidermis surface, avoid excessive flow or irritation. For example, a single cure for tinea pedis requires mist 5-10 times (approximately 0.5-1mL).
3. Post medication cure
Natural drying: After mist, wait for 1-2 minutes for the medicine to naturally dry and form a protective film. Do not rub or cover clothing.
Nozzle unpolluteding: Remove the nozzle every week, rinse the interior with warm water, air dry and reinstall to prevent clogging.
Waste disposal: Empty bottles should be classified and recycled as medical waste to avoid polluting the environment.
Storage and expiration date management
Storage conditions
Unopened: Sealed, stored away from light at 5-25 ℃, and protected from direct sunlight.
After opening: Use within 6 months. If the medicine changes color (such as yellowing) or precipitates, stop using immediately.
Validity period identification
Outer packaging: Label the production date and expiration date (e.g. "EXP 2027.09"), expired medicine should be treated as hazardous waste.
Frequently Asked Questions and Answers
1.Can it be used on the face?
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Do not spray on sensitive areas such as the face, eye area, and mucous membranes of the mouth and nose to avoid the risk of irritation.
2. How to deal with leakage?
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If missed once, spray normally at the next application time without doubling the dosage.
3.How to prevent recurrence after the end of the cure course?
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Keep your skin dry and avoid sharing slippers and towels.
Patients with athlete's foot should regularly change their shoes and socks, and use antifungal shoe powder.
The standardized use of terbinafine hydrochloride spray can effectively control superficial fungal permeate and improve the quality of life. During medication, it is necessary to closely observe changes in symptoms and consult professionals promptly if there are any abnormalities.
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