Nicotinamide riboside chloride powder is a white to off white crystalline compound with the chemical formula C ₁₁ H ₁₅ ClN ₂ O ₅. It is the chloride salt form of Nicotinamide Riboside (NR) and is a derivative of vitamin B3 (niacin). NR is composed of nicotinamide (the active form of vitamin B3) combined with ribose (a five carbon sugar), and its stability and solubility are enhanced by its chloride salt form. Easy to dissolve in water, convenient to make into powder or capsule form for oral supplementation. It increases NAD ⁺ levels, activates Sirtuins, and delays cellular aging. Animal experiments have shown that it can prolong lifespan and improve age-related metabolic decline.
At the same time, our company not only provides pure powders, but also tablets and injections. If needed, please feel free to contact us at any time.
Our products
| Product Name | Nicotinamide Riboside Chloride Powder | Nicotinamide Riboside Tablets | Nicotinamide Riboside Capsules | Nicotinamide Riboside Injection | Nicotinamide Riboside Nasal Spray |
| Product Type | Powder | Tablet | Capsules | liquid | Paste |
| Product Purity | ≥99% | ≥99% | ≥99% | ≥99% | ≥99% |
| Product Specifications | 100g/1kg/etc. | 50mg/100mg/500mg | 500mg/80 capsules | 1ml/50mg | 10ml/15ml |
| Product Form | Organic synthesis | Take Orally | Take Orally | Organic synthesis | External application |
Nicotinamide Riboside Chloride COA
 |
||
| Certificate of Analysis | ||
| Compound name | Nicotinamide riboside chloride | |
| Grade | Pharmaceutical grade | |
| CAS No. | 23111-00-4 | |
| Quantity | Customized | |
| Packaging standard | Customized | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090056 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |  |
|
| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.38% |
| Loss on drying | ≤1.0% | 0.27% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.80% |
| Single impurity | <0.8% | 0.45% |
| Total microbial count | ≤750cfu/g | 70 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 400ppm |
| Storage | Store in a sealed, dark, and dry place below 2-8°C | |
|
|
||
|
|
||
| Chemical Formula | C70H92ClN17O14 |
| Exact Mass | 1429.67 |
| Molecular Weight | 1431.06 |
| m/z | 1429.67(100.0%), 1430.67(75.7%), 1431.67(32.0%), 1431.68(28.3%), 1432.67(24.2%), 1433.67(9.0%), 1430.67(6.3%), 1432.68(6.1%), 1431.67(4.5%), 1431.67(2.9%), 1434.68(2.2%), 1432.68(2.2%), 1432.66(1.9%), 1432.67(1.8%), 1433.67(1.5%), 1433.68(1.3%), 1430.68(1.1%) |
| Elemental Analysis | C,58.75; H,6.48; Cl,2.48; N,16.64; O,15.65 |
Nicotinamide riboside chloride powder (NR chloride for short) is one of the most attention grabbing cutting-edge ingredients in the field of nutritional science in recent years. As a derivative of vitamin B3 (niacin), it exhibits great potential in anti-aging, energy metabolism, neuroprotection, metabolic disease intervention, and other fields by efficiently increasing intracellular levels of nicotinamide adenine dinucleotide (NAD ⁺).
Anti aging: Activate Sirtuins to delay cellular aging
The relationship between Sirtuins and cellular aging
Sirtuins are a class of histone deacetylase family proteins that rely on NAD+, including seven members SIRT1-SIRT7 in mammals. They are widely distributed within cells and participate in regulating various biological processes, closely related to cellular aging. Sirtuins can regulate the activity of various metabolic enzymes through deacetylation, affecting the metabolism of sugars, fats, and proteins. For example, SIRT1 can activate peroxisome proliferator activated receptor gamma co activator factor 1 alpha (PGC-1 alpha), promote mitochondrial biogenesis and fatty acid oxidation, and improve cellular energy metabolism efficiency.
As cells age, the activity of Sirtuins decreases, leading to metabolic disorders. Maintaining the activity of Sirtuins helps to maintain normal metabolic function of cells. Oxidative stress is one of the important triggers of cellular aging, and the excess reactive oxygen species (ROS) produced can damage biomolecules such as DNA, proteins, and lipids within cells. Sirtuins can alleviate cellular damage caused by oxidative stress by activating the expression and activity of antioxidant enzymes. For example, SIRT3 can deacetylate and activate manganese superoxide dismutase (MnSOD), enhance the cell's ability to clear ROS, and protect cells from oxidative damage.
Mechanism of Nicotinamide Riboside Chloride Activating Sirtuins
Nicotinamide Riboside Chloride is first converted to NAD+in the body, which serves as a coenzyme for Sirtuins and is necessary for its deacetylase activity. When Nicotinamide Riboside Chloride supplementation leads to an increase in NAD+levels, Sirtuins are able to bind more NAD+, thereby enhancing their deacetylase activity. Specifically, Sirtuins catalyze the deacetylation of lysine residues in substrate proteins, while hydrolyzing NAD+into nicotinamide and O-acetyl ADP ribose.
This process not only changes the acetylation state of substrate proteins, affecting their function and activity, but also participates in intracellular signaling and metabolic regulation by consuming NAD+and producing products such as nicotinamide. Nicotinamide Riboside Chloride provides sufficient substrate for Sirtuins by increasing NAD+levels, enabling them to continuously exert deacetylation and regulate a series of biological processes related to cellular aging.
The specific role in delaying the process of cellular aging
By activating Sirtuins, Nicotinamide Riboside Chloride can improve cellular energy metabolism. As mentioned earlier, SIRT1 activates PGC-1 α to promote mitochondrial biogenesis and fatty acid oxidation, improving the energy production efficiency of cells. Research has shown that supplementing Nicotinamide Riboside Chloride in aging cells improves mitochondrial function, increases ATP production, enhances cellular metabolic activity, and thus delays the process of cellular aging.
Nicotinamide Riboside Chloride enhances the antioxidant defense ability of cells by activating Sirtuins. SIRT3 activates antioxidant enzymes such as MnSOD, enhances the cell's ability to clear ROS, and reduces oxidative stress damage to intracellular biomolecules. The experiment found that in the aging model, treatment with Nicotinamide Riboside Chloride resulted in a decrease in intracellular ROS levels, a reduction in the content of oxidative damage markers, and an improvement in cell survival rate and function.
Nicotinamide Riboside Chloride participates in DNA damage repair by activating Sirtuins, maintaining genomic stability. Members such as SIRT1 can regulate the activity and expression of DNA damage repair related proteins, promoting timely repair of DNA damage. Supplementing with Nicotinamide Riboside Chloride can enhance the DNA repair ability of cells induced by radiation or chemical substances, reduce the accumulation of DNA damage, and lower the risk of cellular carcinogenesis and aging.
Sirtuins are also involved in regulating the cell cycle and apoptosis process. Nicotinamide Riboside Chloride activates Sirtuins, which can affect the expression of cell cycle proteins and the regulation of cell cycle checkpoints, enabling cells to complete the cell cycle process normally and avoiding aging caused by cell cycle arrest. Meanwhile, Sirtuins can inhibit the expression of pro apoptotic proteins, promote the activity of anti apoptotic proteins, reduce cell apoptosis, and maintain the stability of cell quantity and function.
Energy Metabolism: Improving Exercise Performance and Relieving Fatigue
The mechanism of action in energy metabolism
The tricarboxylic acid cycle (TCA cycle) is one of the core pathways for energy production in cells. It oxidizes and breaks down nutrients such as carbohydrates, fats, and proteins to produce carbon dioxide and water, and releases energy. NAD+plays a crucial role in the TCA cycle, acting as a hydrogen receptor to receive hydrogen atoms removed from substrates, forming NADH. Nicotinamide riboside chloride powder promotes the normal functioning of the TCA cycle by increasing NAD+levels in the body, increases NADH production, and provides sufficient substrate for subsequent oxidative phosphorylation processes.
Oxidative phosphorylation is the main way for cells to produce ATP (adenosine triphosphate, the main energy currency of cells). In the process of oxidative phosphorylation, NADH transfers hydrogen atoms to the mitochondrial respiratory chain, and through a series of electron transfer reactions, ultimately reduces oxygen to water while releasing energy for ATP synthesis. The increased NADH levels in Nicotinamide Riboside Chloride can enhance the efficiency of oxidative phosphorylation, increase the rate of ATP synthesis, and provide more energy support to cells.
Positive impact on athletic performance
In endurance sports such as long-distance running, swimming, and cycling, the body's energy supply mainly relies on aerobic metabolism. Nicotinamide Riboside Chloride increases NAD+levels, promotes TCA cycle and oxidative phosphorylation, enhances ATP synthesis, and provides sustained energy support for muscle contraction. Research has shown that animals in the experimental group supplemented with Nicotinamide Riboside Chloride can persist for longer periods of time in endurance swimming tests, with significant differences compared to the control group.For human athletes, long-term supplementation of this substance may also help prolong exercise time and improve endurance performance.
During endurance exercise, the body needs to constantly adjust the utilization ratio of energy substances to adapt to the intensity of the exercise. The role of Nicotinamide Riboside Chloride in regulating sugar and fat metabolism enables it to help the body utilize sugar and fat as energy sources more efficiently. In the early stages of exercise, it can promote the breakdown and utilization of fat, reduce excessive dependence on glycogen, thereby delaying glycogen depletion and improving the persistence of exercise. As exercise time prolongs, when glycogen reserves decrease, it can ensure that the body continues to effectively utilize fat for energy supply, maintaining the progress of exercise
Improve strength and speed performance in sports
Strength and speed movements, such as weightlifting, sprinting, and jumping, mainly rely on anaerobic metabolism and the rapid contraction ability of muscles. Nicotinamide Riboside Chloride provides more abundant ATP for muscle contraction by improving energy metabolism efficiency. ATP is the direct energy source for muscle contraction, and sufficient ATP supply can enhance the contraction ability of muscle fibers, enabling athletes to lift heavier weights during strength training and generate greater explosive power during speed movements.
In addition to directly acting on muscle cells, Nicotinamide Riboside Chloride may also improve motor performance by affecting the function of the nervous system. NAD+participates in the energy metabolism and signal transduction processes of nerve cells. Supplementing with Nicotinamide Riboside Chloride can increase the excitability and conduction velocity of nerve cells, and improve the coordination between nerve muscles. This enables athletes to more accurately control muscle contractions, improve their skills and efficiency in exercise, and achieve better results in strength and speed movements.
The role of relieving exercise fatigue
During exercise, the body's energy metabolism accelerates, producing a large amount of reactive oxygen species (ROS) such as superoxide anions, hydrogen peroxide, and hydroxyl radicals. These ROS can attack biomolecules inside cells, such as lipids, proteins, and DNA, causing cell damage and dysfunction, leading to oxidative stress. Oxidative stress is one of the important causes of exercise fatigue, which affects muscle contraction ability, energy metabolism, and nerve conduction, making athletes feel tired and powerless.
Nicotinamide Riboside Chloride activates a range of antioxidant enzyme activities, such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), by increasing NAD+levels. These antioxidant enzymes can clear excessive ROS in the body and alleviate the damage of oxidative stress to cells. Research has shown that supplementing nicotinamide riboside chloride powder can significantly reduce the levels of oxidative stress markers in muscle tissue after exercise, protect the integrity of cell structure and function, and alleviate exercise fatigue.
The mainstream chemical synthesis takes tetra-O-acetyl-D-ribofuranose and nicotinamide as starting materials under anhydrous inert atmosphere. The ribose derivative is activated by triflate catalyst in acetonitrile at low temperature, then coupled with nicotinamide to form acetyl-protected nicotinamide riboside intermediate, selectively yielding the stable β-isomer.
Mild acidic methanol removes acetyl protective groups without damaging glycosidic linkages. After impurity removal through ion exchange, chloride solution conducts anion replacement to form the target chloride salt.
The liquid is vacuum concentrated, recrystallized with methanol-acetone solvent and low-temperature dried into white crystalline powder. All procedures are tracked by HPLC and NMR to meet pharmaceutical purity standards. Enzymatic synthesis serves as a mild green lab route, utilizing nucleosidase catalysis in water phase for small-scale preparation.
FAQ
What is nicotinamide riboside chloride for?
+
-
Taking nicotinamide riboside can help raise low NAD+ levels. People use nicotinamide riboside for anti-aging effects, high cholesterol, high blood pressure, Alzheimer disease, obesity, and many other purposes, but there is no good scientific evidence to support these uses.
Is nicotinamide riboside chloride the same as NAD?
+
-
Nicotinamide riboside (NR) is an additional salvageable NAD+ precursor with a two-step [10] or three-step pathway [11] to form NAD+ (Figure 1). In mammals, the most common precursor is NAM, which can further be used to form NMN by the rate-limiting enzyme, phosphoribosyltransferase (NAMPT) .
Does Nicotinamide riboside reverse aging?
+
-
Activates enzymes that may promote healthy aging
Nicotinamide riboside helps increase NAD+ levels in your body. In response, NAD+ activates certain enzymes that may promote healthy aging. One group is sirtuins, which appear to improve lifespan and overall health in animals.
Hot Tags: nicotinamide riboside chloride powder, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, 3 4 5 Trimethoxy trans stilbene, Meprednisone Hemisuccinate CAS 27303 92 0, API Researching Only , 3-Hydroxytyramine, 6 methylergoline 8beta carboxylic Acid CAS 5878 43 3, tetramisole hydrochloride powder